Article

Loss of <i>PAX4</i> results in disrupted endocrine pancreas development and neonatal diabetes in pigs

2026-05-26

Abstract excerpt

Variants in the human PAX4 gene are associated with both monogenic and complex forms of diabetes, yet their pathogenic effects remain difficult to define in models that accurately mimic human islet architecture and neonatal metabolic transitions. Here, we created a porcine PAX4 loss-of-function model using CRISPR/Cas9 cytidine deaminase base editing to introduce a premature stop codon in the PAX4 coding sequenc...

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Literature Corpus work: 5f7bc82f-6bcd-56e7-91f2-8bd58b8c696c
DOI: 10.64898/2026.05.21.727014

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