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Article

Generation of insulin-deficient piglets by disrupting INS gene using CRISPR/Cas9 system.

Transgenic research - 1 Jun 2018

Cho Bumrae, Kim Su Jin, Lee Eun-Jin, Ahn Sun Mi, Lee Jin Seok, Ji Dal-Young, Lee Kiho, Kang Jung-Taek

Abstract excerpt

Diabetes mellitus is a chronic disease with accompanying severe complications. Various animal models, mostly rodents due to availability of genetically modified lines, have been used to investigate the pathophysiology of diabetes. Using pigs for diabetic research can be beneficial because of their similarity in size, pathogenesis pathway, physiology, and metabolism with human. However, the use of pigs for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29691708
DOI: 10.1007/s11248-018-0074-1

Genes

INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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