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Preparation of a new type 2 diabetic miniature pig model via the CRISPR/Cas9 system

28 Oct 2019

Abstract excerpt

Diabetes has become one of the major noninfectious diseases that seriously endanger public health. The formation of islet amyloid polypeptide (IAPP) affects the normal physiological functions of the body, such as glucose metabolism and lipid metabolism. The mature human IAPP protein (hIAPP) has a strong tendency to misfold and is considered to be one of the major causes of amyloid changes in islets. Deposition of...

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PMID: 31659151
DOI: 10.1038/s41419-019-2056-5

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