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Article

Phenylethanolamine N-methyltransferase gene polymorphisms associate with crisis pain in sickle cell disease patients.

Pharmacogenomics - 1 Mar 2020

Sadhu Nilanjana, Jhun Ellie H, Posen Andrew, Yao Yingwei, He Ying, Molokie Robert E, Wilkie Diana J, Wang Zaijie J

Abstract excerpt

Aim: Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of sympathetic neurotransmitter norepinephrine to epinephrine. We examined the association of PNMT polymorphisms with acute and chronic pain in sickle cell disease (SCD). Methods: Utilization of emergency care owing to painful crisis was used as a marker for acute pain in 131 patients with SCD. Results: rs876493 A allele, rs2934965 T...

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Identifiers

PMID: 32162598
DOI: 10.2217/pgs-2019-0096
PMCID: PMC7202258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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