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Article

Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain in sickle cell disease.

Anesthesia and analgesia - 1 Nov 2014

Jhun Ellie, He Ying, Yao Yingwei, Molokie Robert E, Wilkie Diana J, Wang Zaijie Jim

Abstract excerpt

BACKGROUND: Pain in sickle cell disease (SCD) is characterized by episodes of acute pain, primarily responsible for acute health care utilization, and persistent chronic pain. Pain severity and frequency vary significantly among patients with SCD. In this study, we investigated the possible contribution of monoamine gene polymorphisms to pain variation. METHODS: Adult subjects with SCD completed PAINReportIt, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

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Share to Polymorphism, Genetic

Share to Polymorphism, Single Nucleotide

Share to Receptors, Dopamine D3

Source

Open in PubMed Open full text

Identifiers

PMID: 25102390
DOI: 10.1213/ANE.0000000000000382
PMCID: PMC4205211

Genes

COMT
SCD
DRD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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