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Article

Catechol-O-methyltransferase gene (COMT) is associated with neurocognitive functioning in patients with sickle cell disease.

Current research in translational medicine - 1 Jun 2024

Heitzer Andrew M, Rashkin Sara R, Trpchevska Ana, Longoria Jennifer N, Rampersaud Evadnie, Olufadi Yunusa, Wang Winfred C, Raches Darcy, Potter Brian, Steinberg Martin H, King Allison A, Kang Guolian, Takemoto Clifford M, Hankins Jane S

Abstract excerpt

PURPOSE: Neurocognitive impairment is a common and debilitating complication of sickle cell disease (SCD) resulting from a combination of biological and environmental factors. The catechol-O-methyltransferase (COMT) gene modulates levels of dopamine availability in the prefrontal cortex. COMT has repeatedly been implicated in the perception of pain stimuli and frequency of pain crises in patients with SCD and is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38244277
DOI: 10.1016/j.retram.2023.103433
PMCID: PMC11106217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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