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Article

Association of COMT rs4680 Genotype With Chronic Neuropathic Pain Experience in Patients With Sickle Cell Disease.

Pain management nursing : official journal of the American Society of Pain Management Nurses - 1 Jun 2025

Islam Abigail R, Kiros Gebre-Egziabher, Ajiboye Rachael O, Powell-Roach Keesha, Ezenwa Miriam O, Reams R Renee, Molokie Robert E, Wang Zaijie Jim, Yao Yingwei, Wilkie Diana J

Abstract excerpt

PURPOSE: The pain experience of patients with sickle cell disease (SCD) frequently consists of episodes of acute exacerbation. However, recent studies suggest that many patients who suffer from SCD have symptoms of chronic neuropathic pain. Additional research is needed to determine what role genotype plays in the patient's pain phenotype experience in SCD. The purpose of our project was to determine whether a...

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Share to Genotype
Share to Anemia, Sickle Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

Share to Chronic Pain

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Share to Neuralgia

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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 39734110
DOI: 10.1016/j.pmn.2024.11.010
PMCID: PMC12103282

Genes

SCD
COMT
MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Association of COMT rs4680 Genotype With Chronic Neuropathic Pain Experience in Patients With Sickle Cell Disease.PMID 39734110Read ↗

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