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Article

S100B single nucleotide polymorphisms exhibit sex-specific associations with chronic pain in sickle cell disease in a largely African-American cohort.

PloS one - 1 Jan 2020

Jhun Ellie H, Sadhu Nilanjana, He Ying, Yao Yingwei, Wilkie Diana J, Molokie Robert E, Wang Zaijie Jim

Abstract excerpt

BACKGROUND: Pain in sickle cell disease (SCD) is severe and multifaceted resulting in significant differences in its frequency and intensity among individuals. In this study, we examined the influence of S100B gene single nucleotide polymorphisms (SNP) on acute and chronic pain variability in SCD. METHODS: Composite pain index (CPI) scores captured chronic pain. Painful crisis related emergency care utilization...

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Share to Anemia, Sickle Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

Share to Polymorphism, Single Nucleotide

Share to S100 Calcium Binding Protein beta Subunit

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Source

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Identifiers

PMID: 32379790
DOI: 10.1371/journal.pone.0232721
PMCID: PMC7205279

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