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Article

HUMAN STUDY COMT and DRD3 haplotype-associated pain intensity and acute care utilization in adult sickle cell disease.

Experimental biology and medicine (Maywood, N.J.) - 1 Sept 2022

Powell-Roach Keesha L, Yao Yingwei, Wallace Margaret R, Chamala Srikar, Cruz-Almeida Yenisel, Jhun Ellie, Molokie Robert E, Wang Zajie Jim, Wilkie Diana J

Abstract excerpt

A previous exploratory analysis of a COMT gene single-nucleotide polymorphism (SNP) and a DRD3 SNP by our group suggested possible contributions to pain-related acute care utilization in people with sickle cell disease (SCD). Our aim was to extend the analysis to gene-spanning haplotypes of COMT SNPs and DRD3 SNPs to investigate possible associations with pain intensity and pain-related acute care utilization in...

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Share to Anemia, Sickle Cell
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Receptors, Dopamine D3

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Identifiers

PMID: 35285297
DOI: 10.1177/15353702221080716
PMCID: PMC9554168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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