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Article

Transient receptor potential polymorphism and haplotype associate with crisis pain in sickle cell disease.

Pharmacogenomics - 1 Apr 2018

Jhun Ellie H, Hu Xiaoyu, Sadhu Nilanjana, Yao Yingwei, He Ying, Wilkie Diana J, Molokie Robert E, Wang Zaijie J

Abstract excerpt

AIM: Episodes of acute pain crisis contribute to considerable morbidity and mortality in sickle cell disease (SCD). Incomprehensive understanding of the underlying pain heterogeneity results in inadequate pain management. The transient receptor potential (TRP) family of voltage-gated ion channels acts as sensory transducers of diverse noxious stimuli. We performed an association study of polymorphisms in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29620434
DOI: 10.2217/pgs-2017-0198
PMCID: PMC6275563

Genes

SCD
TRPA1
TRPV1

Provenance

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