Article
Exome-Wide Sequencing Study Identified Genetic Variants Associated With Sarcopenic Obesity.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Apr 2024
Xu Qian, Zhao Qi-Gang, Ma Xin-Ling, Yan Shan-Shan, Han Bai-Xue, Song Zi-Tong, Bu Fan, Li Kuan, Zhang Lei, Pei Yu-Fang
Abstract excerpt
Sarcopenic obesity (SO) is an age-related disease characterized by the coexistence of excessive adiposity and low muscle mass or function. Although obesity and sarcopenia are heritable conditions, the genetic determinants of SO have not been fully understood. We conducted a large-scale exome-wide association analysis of SO in a sequenced sample of 2 887 cases and 113 284 controls and an imputed sample of 4 003...
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