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Article

Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8

14 Aug 2018

Abstract excerpt

Significance Oligodendrocyte precursor cells (OPCs) constitute the main proliferative cells in the adult brain and deregulation of OPC proliferation-differentiation balance results in either glioma formation or defective (re)myelination. Mutations in chromatin remodelers CHD7 and CHD8 are the cause of CHARGE syndrome and some autism spectrum disorders (ASD). Here we show that Chd7 protects OPCs from apoptosis by...

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PMID: 30108144
DOI: 10.1073/pnas.1802620115

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