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Article

Developmental pyrethroid exposure and age influence phenotypes in a Chd8 haploinsufficient autism mouse model.

Scientific reports - 1 Apr 2022

Jiménez Jessica A, Simon Jeremy M, Hu Wenxin, Moy Sheryl S, Harper Kathryn M, Liu Chih-Wei, Lu Kun, Zylka Mark J

Abstract excerpt

Hundreds of genes have been associated with autism spectrum disorder (ASD), including loss-of-function mutations in chromodomain helicase DNA binding protein 8 (Chd8). Environmental factors also are implicated in autism risk and have the potential to exacerbate phenotypes in genetically sensitized backgrounds. Here we investigate transcriptional and behavioral phenotypes in a Chd8 haploinsufficient (Chd8V986*/+)...

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Identifiers

PMID: 35365720
DOI: 10.1038/s41598-022-09533-x
PMCID: PMC8975859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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