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Article

Histone variant H3.3 maintains a decondensed chromatin state essential for mouse preimplantation development

1 Aug 2013

Abstract excerpt

Histone variants can replace canonical histones in the nucleosome and modify chromatin structure and gene expression. The histone variant H3.3 preferentially associates with active chromatin and has been implicated in the regulation of a diverse range of developmental processes. However, the mechanisms by which H3.3 may regulate gene activity are unclear and gene duplication has hampered an analysis of H3.3...

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PMID: 23903189
DOI: 10.1242/dev.095513

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