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Article

Nonsense Mutations in the Yeast SUP35 Gene Affect the [PSI+] Prion Propagation.

International journal of molecular sciences - 28 Feb 2020

Trubitsina Nina P, Zemlyanko Olga M, Bondarev Stanislav A, Zhouravleva Galina A

Abstract excerpt

The essential SUP35 gene encodes yeast translation termination factor eRF3. Previously, we isolated nonsense mutations sup35-n and proposed that the viability of such mutants can be explained by readthrough of the premature stop codon. Such mutations, as well as the prion [PSI+], can appear in natural yeast populations, and their combinations may have different effects on the cells. Here, we analyze the effects...

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Identifiers

PMID: 32121268
DOI: 10.3390/ijms21051648
PMCID: PMC7084296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nonsense Mutations in the Yeast SUP35 Gene Affect the [PSI+] Prion Propagation.PMID 32121268Read ↗

Propagation of the yeast prion-like [psi+] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor.Semantic proximity Read ↗

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SFP1-mediated prion-dependent lethality is caused by increased Sup35 aggregation and alleviated by Sis1.Semantic proximity Read ↗

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