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Article

SFP1-mediated prion-dependent lethality is caused by increased Sup35 aggregation and alleviated by Sis1.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Dec 2016

Matveenko Andrew G, Drozdova Polina B, Belousov Mikhail V, Moskalenko Svetlana E, Bondarev Stanislav A, Barbitoff Yury A, Nizhnikov Anton A, Zhouravleva Galina A

Abstract excerpt

[PSI+ ] is the prion form of the translation termination factor Sup35 (eRF3); [PSI+ ] strains display nonsense suppression. Another prion-like element, [ISP+ ], is linked to antisuppression in a specific background. Transcriptional regulator Sfp1 was shown to be responsible for [ISP+ ] propagation. In this work, we identified SFP1 as a multicopy inducer of [PSI+ ]-dependent lethality. Sfp1 is likely to...

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Identifiers

PMID: 27734597
DOI: 10.1111/gtc.12444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SFP1-mediated prion-dependent lethality is caused by increased Sup35 aggregation and alleviated by Sis1.PMID 27734597Read ↗

Nonsense Mutations in the Yeast SUP35 Gene Affect the [PSI+] Prion Propagation.Semantic proximity Read ↗

Propagation of the yeast prion-like [psi+] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor.Semantic proximity Read ↗

Non-Mendelian determinant [ISP+] in yeast is a nuclear-residing prion form of the global transcriptional regulator Sfp1.Semantic proximity Read ↗

Detection system- and strain-dependent diversity of de novo [PSI+] prion generation and phenotypes in Saccharomyces cerevisiae.Semantic proximity Read ↗

[Search for the genes critical for propagation of the prion-like antisuppressor determinant [ISP+] in yeast using insertion library].Semantic proximity Read ↗

Functions of yeast Hsp40 chaperone Sis1p dispensable for prion propagation but important for prion curing and protection from prion toxicity.Semantic proximity Read ↗

Translation termination efficiency can be regulated in Saccharomyces cerevisiae by environmental stress through a prion-mediated mechanism.Semantic proximity Read ↗

Interaction between yeast Sup45p (eRF1) and Sup35p (eRF3) polypeptide chain release factors: implications for prion-dependent regulation.Semantic proximity Read ↗

Epigenetic control of polyamines by the prion [PSI+].Semantic proximity Read ↗

The yeast non-Mendelian factor [ETA+] is a variant of [PSI+], a prion-like form of release factor eRF3.Semantic proximity Read ↗

Mutants of the Paf1 complex alter phenotypic expression of the yeast prion [PSI+].Semantic proximity Read ↗

Haploid yeast cells undergo a reversible phenotypic switch associated with chromosome II copy number.Semantic proximity Read ↗

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