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Article

Extracellular Juxtamembrane Segment of ADAM17 Interacts with Membranes and Is Essential for Its Shedding Activity.

Biochemistry - 29 Sept 2015

Düsterhöft Stefan, Michalek Matthias, Kordowski Felix, Oldefest Mirja, Sommer Anselm, Röseler Jona, Reiss Karina, Grötzinger Joachim, Lorenzen Inken

Abstract excerpt

A wide variety of biological processes including differentiation, regeneration, and cancer progression are regulated by shedding of membrane-anchored proteins. One of the major sheddases is A Disintegrin And Metalloprotease-17 (ADAM17) whose extracellular region consists of a pro-, a catalytic, a disintegrin-, and a membrane-proximal domain (MPD) as well as a short juxtamembrane segment of 17 amino acid residues...

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Source

Identifiers

PMID: 26348730
DOI: 10.1021/acs.biochem.5b00497

Genes

ADAM17
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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