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Article

Molecular switch in human diseases-disintegrin and metalloproteinases, ADAM17

28 Jun 2021

Abstract excerpt

The ADAMs (a disintegrin and metalloproteinase) are a family of cell surface proteins with crucial roles in the regulation of cell adhesion, cell proliferation to migration, proteolysis and cell signaling transduction pathways. Among these enzymes, the ADAM17 shows significant effects in the "ectodomain shedding" of its substrates such as cytokines (e.g., tumor necrosis factor α, TNFα), growth factors (e.g.,...

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PMID: 34182543
DOI: 10.18632/aging.203200

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