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Article

Investigation of sirtuin 1 polymorphisms in relation to the risk of colorectal cancer by molecular subtype.

Scientific reports - 25 Feb 2020

Hrzic Rok, Simons Colinda C J M, Schouten Leo J, van Engeland Manon, Brandt Piet van den, Weijenberg Matty P

Abstract excerpt

Sirtuin 1 (SIRT1), a histone deacetylase, is involved in maintenance of genetic stability, inflammation, immune response, metabolism (energy-sensing molecule) and colorectal tumorigenesis. We investigated SIRT1's specific role in colorectal tumorigenesis by studying SIRT1 polymorphisms in relation to colorectal cancer (CRC) risk by microsatellite instability (MSI) and CpG island methylator phenotype (CIMP)...

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Identifiers

PMID: 32098999
DOI: 10.1038/s41598-020-60300-2
PMCID: PMC7042277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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