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Article

Functional sequence variants within the SIRT1 gene promoter in indirect inguinal hernia.

Gene - 1 Aug 2014

Han Qingluan, Zhang Yu, Li Wei, Fan Hongjin, Xing Qining, Pang Shuchao, Yan Bo

Abstract excerpt

Inguinal hernia is a common surgical disease, for which genetic factors have been suggested to play a role. Sirtuin 1 (SIRT1), a highly conserved NAD-dependent class III deacetylase, has been implicated in human diseases. Since SIRT1 regulates differentiation and proliferation of human skeletal muscles and fibroblasts, we speculated that misregulation of SIRT1 gene, caused by DNA sequence variants (DSVs) within...

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Identifiers

PMID: 24875419
DOI: 10.1016/j.gene.2014.05.058

Genes

SIRT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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