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MTHFR C677T and A1298C variant genotypes and the risk of microsatellite instability among Iranian colorectal cancer patients.

Cancer genetics and cytogenetics - 1 Mar 2010

Naghibalhossaini Fakhraddin, Mokarram Pooneh, Khalili Islam, Vasei Mohammad, Hosseini Seyed Vahid, Ashktorab Hassan, Rasti Mozhgan, Abdollahi Kourosh

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the folate metabolic pathway. We aimed to test the hypothesis that C677T and A1298C variants of MTHFR predispose to microsatellite instable (MSI) colorectal cancer. We determined MTHFR genotypes in 175 sporadic colorectal cancer patients and a total of 231 normal controls in Shiraz, Southern Iran. Among the genotypes found in our samples, MTHFR CT and...

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Identifiers

PMID: 20193847
DOI: 10.1016/j.cancergencyto.2009.11.014
PMCID: PMC3684801

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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