Article
Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma
3 May 2012
Abstract excerpt
BACKGROUND: The class III histone deacetylase SIRT1 is a nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase, and has been reported to serve diverse roles in various biological processes, such as caloric restriction, apoptosis, neuronal protection, cell growth, differentiation and tumourigenesis. With respect to tumourigenesis, there have been conflicting data supporting whether SIRT1 act as a tumour...
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