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Article

Wnt5b integrates Fak1a to mediate gastrulation cell movements via Rac1 and Cdc42.

Open biology - 1 Feb 2020

Hung I-Chen, Chen Tsung-Ming, Lin Jing-Ping, Tai Yu-Ling, Shen Tang-Long, Lee Shyh-Jye

Abstract excerpt

Focal adhesion kinase (FAK) mediates vital cellular pathways during development. Despite its necessity, how FAK regulates and integrates with other signals during early embryogenesis remains poorly understood. We found that the loss of Fak1a impaired epiboly, convergent extension and hypoblast cell migration in zebrafish embryos. We also observed a clear disturbance in cortical actin at the blastoderm margin and...

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Identifiers

PMID: 32097584
DOI: 10.1098/rsob.190273
PMCID: PMC7058935

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