Article
Focal adhesion kinase protein regulates Wnt3a gene expression to control cell fate specification in the developing neural plate.
Molecular biology of the cell - 1 Jul 2011
Fonar Yuri, Gutkovich Yoni E, Root Heather, Malyarova Anastasia, Aamar Emil, Golubovskaya Vita M, Elias Sarah, Elkouby Yaniv M, Frank Dale
Abstract excerpt
Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase protein localized to regions called focal adhesions, which are contact points between cells and the extracellular matrix. FAK protein acts as a scaffold to transfer adhesion-dependent and growth factor signals into the cell. Increased FAK expression is linked to aggressive metastatic and invasive tumors. However, little is known about its normal...
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