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Article

Diverse Fgfr1 signaling pathways and endocytic trafficking regulate mesoderm development.

Genes & development - 25 Jun 2024

Clark James F, Soriano Philippe

Abstract excerpt

The fibroblast growth factor (FGF) pathway is a conserved signaling pathway required for embryonic development. Activated FGF receptor 1 (FGFR1) drives multiple intracellular signaling cascade pathways, including ERK/MAPK and PI3K/AKT, collectively termed canonical signaling. However, unlike Fgfr1-null embryos, embryos containing hypomorphic mutations in Fgfr1 lacking the ability to activate canonical downstream...

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Share to Embryonic Development
Share to Endocytosis
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mesoderm

Share to Protein Transport

Share to Receptor, Fibroblast Growth Factor, Type 1

Share to Signal Transduction

Source

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Identifiers

PMID: 38834239
DOI: 10.1101/gad.351593.124
PMCID: PMC11216173

Genes

FGFR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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