Diversity of HLA Class I and Class II blocks and conserved extended haplotypes in Lacandon Mayans.

doi:10.1038/s41598-020-58897-5

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Article

Diversity of HLA Class I and Class II blocks and conserved extended haplotypes in Lacandon Mayans.

Scientific reports - 24 Feb 2020

Barquera Rodrigo, Zuniga Joaquin, Flores-Rivera José, Corona Teresa, Penman Bridget S, Hernández-Zaragoza Diana Iraíz, Soler Manuel, Jonapá-Gómez Letisia, Mallempati Kalyan C, Yescas Petra, Ochoa-Morales Adriana, Barsakis Konstantinos, Aguilar-Vázquez José Artemio, García-Lechuga Maricela, Mindrinos Michael, Yunis María, Jiménez-Alvarez Luis, Mena-Hernández Lourdes, Ortega Esteban, Cruz-Lagunas Alfredo, Tovar-Méndez Víctor Hugo, Granados Julio, Fernández-Viña Marcelo, Yunis Edmond

Abstract excerpt

Here we studied HLA blocks and haplotypes in a group of 218 Lacandon Maya Native American using a high-resolution next generation sequencing (NGS) method. We assessed the genetic diversity of HLA class I and class II in this population, and determined the most probable ancestry of Lacandon Maya HLA class I and class II haplotypes. Importantly, this Native American group showed a high degree of both HLA...

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PMID: 32094421
DOI: 10.1038/s41598-020-58897-5
PMCID: PMC7039995

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