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Article

Signatures of pathogen-driven selection and Austronesian gene flow of Papua New Guinea HLA alleles.

American journal of human genetics - 4 Jun 2026

Font-Porterias Neus, Nemat-Gorgani Neda, Kichula Katherine M, Al-Hindi Dana R, Harrison Genelle F, Tao Sudan, Zhu Faming, Montero-Martin Gonzalo, Fernández-Viña Marcelo A, Guethlein Lisbeth A, Parham Peter, Oppenheimer Stephen J, Ioannidis Alexander G, Moreno-Estrada Andrés, Pomat William, Mentzer Alexander J, Henn Brenna M, Norman Paul J

Abstract excerpt

Human leukocyte antigen (HLA) class I and II are cell surface proteins that display peptide antigens to immune cells, thereby mediating detection of infected cells and production of antibodies. Pathogen exposure and demographic events, including local adaptation and admixture, have driven and maintained exceptional polymorphism of HLA genes across human populations. Papua New Guinea has a complex demography, with...

Topics

Humans
Papua New Guinea
Selection, Genetic
Alleles
Polymorphism, Single Nucleotide
Gene Flow
HLA Antigens
Genetics, Population

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42086051
DOI: 10.1016/j.ajhg.2026.04.006
PMCID: PMC13277694

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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