Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation.

Brain : a journal of neurology - 1 Mar 2020

Skouras Stavros, Torner Jordi, Andersson Patrik, Koush Yury, Falcon Carles, Minguillon Carolina, Fauria Karine, Alpiste Francesc, Blenow Kaj, Zetterberg Henrik, Gispert Juan D, Molinuevo José L

Abstract excerpt

Research into hippocampal self-regulation abilities may help determine the clinical significance of hippocampal hyperactivity throughout the pathophysiological continuum of Alzheimer's disease. In this study, we aimed to identify the effects of amyloid-β peptide 42 (amyloid-β42) and phosphorylated tau on the patterns of functional connectomics involved in hippocampal downregulation. We identified 48 cognitively...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CA1 Region, Hippocampal

Share to Cognitive Dysfunction

Share to Connectome

Share to Neuroimaging

Share to Neuropsychological Tests

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 32091109
DOI: 10.1093/brain/awaa011
PMCID: PMC7089658

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation.PMID 32091109Read ↗

Distinct effects of amyloid and tau deposition on eigenvector centrality during hippocampal down-regulation: a real-time fMRI virtual reality closed-loop neurofeedback study with CSF biomarkersSemantic proximity Read ↗

The effect of APOE genotype and streamline density volume, on hippocampal CA1 down-regulation: a real-time fMRI virtual reality neurofeedback studySemantic proximity Read ↗

Disrupted excitation-inhibition balance in cognitively normal individuals at risk of Alzheimer’s diseaseSemantic proximity Read ↗

Unveiling paths to Alzheimer’s disease: excitation-inhibition ratio shapes hierarchical dynamicsSemantic proximity Read ↗

ApoE4 and Connectivity-Mediated Spreading of Tau Pathology at Lower Amyloid Levels.Semantic proximity Read ↗

Subject-specific features of excitation/inhibition profiles in neurodegenerative diseasesSemantic proximity Read ↗

Long-term dietary interventions fail to mitigate functional connectivity loss and cognitive decline in the TgF344-AD rat model of Alzheimer’s DiseaseSemantic proximity Read ↗

Edge-Centric Control Energy Follows an Inverted-U Trajectory Through Alzheimer’s Disease ProgressionSemantic proximity Read ↗

Executive function changes before memory in preclinical Alzheimer's pathology: a prospective, cross-sectional, case control study.Semantic proximity Read ↗

Resting-state functional dynamics alterations relate to plasma amyloid markers and explain memory impairments in the TgF344-AD model of Alzheimer’s diseaseSemantic proximity Read ↗

Large-scale reorganization of cortical hierarchy, dynamics, and information processing in subjective cognitive declineSemantic proximity Read ↗

Functional network collapse in neurodegenerative diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.