Article

Edge-Centric Control Energy Follows an Inverted-U Trajectory Through Alzheimer’s Disease Progression

2026-08-05

Abstract excerpt

Alzheimer's disease is a disorder of large-scale brain networks, in which pathology propagates along the connectome and degrades it through synaptic and axonal loss. Cognition depends on distributed regions synchronizing their activity, and that synchronization carries a physical cost, set by how many white-matter connections must be engaged, and how strongly, before a network settles into coordinated activit...

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Literature Corpus work: ddc787bc-7fb6-5f41-a535-5404294c7550
DOI: 10.20944/preprints202608.0321.v1

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