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Article

Executive function changes before memory in preclinical Alzheimer's pathology: a prospective, cross-sectional, case control study.

PloS one - 1 Jan 2013

Harrington Michael G, Chiang Jiarong, Pogoda Janice M, Gomez Megan, Thomas Kris, Marion Sarah Deboard, Miller Karen J, Siddarth Prabha, Yi Xinyao, Zhou Feimeng, Lee Sherri, Arakaki Xianghong, Cowan Robert P, Tran Thao, Charleswell Cherise, Ross Brian D, Fonteh Alfred N

Abstract excerpt

BACKGROUND: Early treatment of Alzheimer's disease may reduce its devastating effects. By focusing research on asymptomatic individuals with Alzheimer's disease pathology (the preclinical stage), earlier indicators of disease may be discovered. Decreasing cerebrospinal fluid beta-amyloid42 is the first indicator of preclinical disorder, but it is not known which pathology causes the first clinical effects. Our...

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Identifiers

PMID: 24260210
DOI: 10.1371/journal.pone.0079378
PMCID: PMC3832547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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