Article
Recovery of muscle mass and muscle oxidative phenotype following disuse does not require GSK-3 inactivation.
Biochimica et biophysica acta. Molecular basis of disease - 1 Jun 2020
Theeuwes Wessel F, Pansters Nicholas A M, Gosker Harry R, Schols Annemie M W J, Verhees Koen J P, de Theije Chiel C, van Gorp Rick H P, Kelders Marco C J M, Ronda Onne, Haegens Astrid, Remels Alexander H V, Langen Ramon C J
Abstract excerpt
BACKGROUND: Physical inactivity contributes to muscle wasting and reductions in mitochondrial oxidative phenotype (OXPHEN), reducing physical performance and quality of life during aging and in chronic disease. Previously, it was shown that inactivation of glycogen synthase kinase (GSK)-3β stimulates muscle protein accretion, myogenesis, and mitochondrial biogenesis. Additionally, GSK-3β is inactivated during...
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