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The Role of GSK-3β in the Regulation of Protein Turnover, Myosin Phenotype, and Oxidative Capacity in Skeletal Muscle under Disuse Conditions.

International journal of molecular sciences - 11 May 2021

Mirzoev Timur M, Sharlo Kristina A, Shenkman Boris S

Abstract excerpt

Skeletal muscles, being one of the most abundant tissues in the body, are involved in many vital processes, such as locomotion, posture maintenance, respiration, glucose homeostasis, etc. Hence, the maintenance of skeletal muscle mass is crucial for overall health, prevention of various diseases, and contributes to an individual's quality of life. Prolonged muscle inactivity/disuse (due to limb immobilization,...

Topics

Animals
Glycogen Synthase Kinase 3 beta
Hindlimb Suspension
Humans
Muscle, Skeletal
Muscular Atrophy
Myosins
Oxidative Stress
Phenotype
Proteolysis

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Identifiers

PMID: 34064895
DOI: 10.3390/ijms22105081
PMCID: PMC8151958

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