Article
Lack of cyclin D3 induces skeletal muscle fiber-type shifting, increased endurance performance and hypermetabolism.
Scientific reports - 24 Aug 2018
Giannattasio Silvia, Giacovazzo Giacomo, Bonato Agnese, Caruso Carla, Luvisetto Siro, Coccurello Roberto, Caruso Maurizia
Abstract excerpt
The mitogen-induced D-type cyclins (D1, D2 and D3) are regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6 that drive progression through the G1 phase of the cell cycle. In skeletal muscle, cyclin D3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. Here, we show that cyclin D3 also performs a novel function, regulating muscle fiber...
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