Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GSK-3α is a central regulator of age-related pathologies in mice.

The Journal of clinical investigation - 1 Apr 2013

Zhou Jibin, Freeman Theresa A, Ahmad Firdos, Shang Xiying, Mangano Emily, Gao Erhe, Farber John, Wang Yajing, Ma Xin-Liang, Woodgett James, Vagnozzi Ronald J, Lal Hind, Force Thomas

Abstract excerpt

Aging is regulated by conserved signaling pathways. The glycogen synthase kinase-3 (GSK-3) family of serine/threonine kinases regulates several of these pathways, but the role of GSK-3 in aging is unknown. Herein, we demonstrate premature death and acceleration of age-related pathologies in the G...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Everolimus
Share to Glycogen Synthase Kinase 3
Share to Knee Joint

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Maleimides

Share to Mechanistic Target of Rapamycin Complex 1

Share to Multiprotein Complexes

Share to Sarcopenia

Share to Sirolimus

Source

Open in PubMed Open full text

Identifiers

PMID: 23549082
DOI: 10.1172/JCI64398
PMCID: PMC3613907

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23549082-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GSK-3α is a central regulator of age-related pathologies in mice.PMID 23549082Read ↗

Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action.Semantic proximity Read ↗

Deletion of Cardiomyocyte Glycogen Synthase Kinase-3 Beta (GSK-3β) Improves Systemic Glucose Tolerance with Maintained Heart Function in Established Obesity.Semantic proximity Read ↗

Cardiac fibroblast GSK-3α mediates adverse myocardial fibrosis via IL-11 and ERK pathwaySemantic proximity Read ↗

Ablation of Shank3 alleviates cardiac dysfunction in aging mice by promoting CaMKII activation and Parkin-mediated mitophagySemantic proximity Read ↗

Blockage of autophagy causes severe skeletal muscle disruption in a mouse model for myofibrillar myopathy 6.Semantic proximity Read ↗

CREG1 promotes autophagy and protects the heart against nutritional stress-induced injury and age-associated hypertrophy, fibrosis and diastolic dysfunctionSemantic proximity Read ↗

Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter.Semantic proximity Read ↗

The mTOR signaling pathway in cardiac agingSemantic proximity Read ↗

Longitudinal characterization of Gaac.1826dupA mice reveals the cardiac, myopathic and biochemical phenotypes of Pompe disease.Semantic proximity Read ↗

Isoform- and Cell Type-Specific Roles of Glycogen Synthase Kinase 3 N-Terminal Serine Phosphorylation in Liver Ischemia Reperfusion Injury.Semantic proximity Read ↗

Glycogen synthase kinase 3 alpha/beta deletion induces precocious growth plate remodeling and cell loss in miceSemantic proximity Read ↗

Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.