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Article

GSK-3α is a central regulator of age-related pathologies in mice.

The Journal of clinical investigation - 1 Apr 2013

Zhou Jibin, Freeman Theresa A, Ahmad Firdos, Shang Xiying, Mangano Emily, Gao Erhe, Farber John, Wang Yajing, Ma Xin-Liang, Woodgett James, Vagnozzi Ronald J, Lal Hind, Force Thomas

Abstract excerpt

Aging is regulated by conserved signaling pathways. The glycogen synthase kinase-3 (GSK-3) family of serine/threonine kinases regulates several of these pathways, but the role of GSK-3 in aging is unknown. Herein, we demonstrate premature death and acceleration of age-related pathologies in the Gsk3a global KO mouse. KO mice developed cardiac hypertrophy and contractile dysfunction as well as sarcomere disruption...

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Identifiers

PMID: 23549082
DOI: 10.1172/JCI64398
PMCID: PMC3613907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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