Article

GSK3 inhibition improves skeletal muscle function and whole-body metabolism in the severe DBA/2J <i>mdx</i> mouse model

2022-02-16

Abstract excerpt

<h4>Introductory paragraph</h4> Duchenne muscular dystrophy (DMD) is a severe X-linked muscle wasting disorder that affects 1 in 5,000 males worldwide 1 . It is caused by the absence of functional dystrophin, which compromises muscle integrity, leading to progressive muscle wasting and weakness 2 . Glucocorticoids are the standard of care for patients with DMD as they delay the loss of ambulation by an average...

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Literature Corpus work: a7d395c4-2974-5ec3-9f06-14eeef97600a
DOI: 10.1101/2022.02.16.480726

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