Article
Skeletal muscle PGC-1β signaling is sufficient to drive an endurance exercise phenotype and to counteract components of detraining in mice.
American journal of physiology. Endocrinology and metabolism - 1 May 2017
Lee Samuel, Leone Teresa C, Rogosa Lisa, Rumsey John, Ayala Julio, Coen Paul M, Fitts Robert H, Vega Rick B, Kelly Daniel P
Abstract excerpt
Peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α and -1β serve as master transcriptional regulators of muscle mitochondrial functional capacity and are capable of enhancing muscle endurance when overexpressed in mice. We sought to determine whether muscle-specific transgenic overexpression of PGC-1β affects the detraining response following endurance training. First, we established and validated...
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