Article
Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action.
Molecular and cellular biology - 1 Oct 2008
Patel Satish, Doble Bradley W, MacAulay Katrina, Sinclair Elaine M, Drucker Daniel J, Woodgett James R
Abstract excerpt
Dysregulation of the protein kinase glycogen synthase kinase 3 (GSK-3) has been implicated in the development of type 2 diabetes mellitus. GSK-3 protein expression and kinase activity are elevated in diabetes, while selective GSK-3 inhibitors have shown promise as modulators of glucose metabolism and insulin sensitivity. There are two GSK-3 isoforms in mammals, GSK-3alpha and GSK-3beta. Mice engineered to lack...
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