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Article

Skeletal muscle immobilisation-induced atrophy: mechanistic insights from human studies

1 Jun 2024

Abstract excerpt

Periods of skeletal muscle disuse lead to rapid declines in muscle mass (atrophy), which is fundamentally underpinned by an imbalance between muscle protein synthesis (MPS) and muscle protein breakdown (MPB). The complex interplay of molecular mechanisms contributing to the altered regulation of muscle protein balance during disuse have been investigated but rarely synthesised in the context of humans. This...

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PMID: 38895777
DOI: 10.1042/cs20231198

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