Article
Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity.
Nature communications - 21 Aug 2017
Tabrez Syed Shamsh, Sharma Ravi Datta, Jain Vaibhav, Siddiqui Atif Ahmed, Mukhopadhyay Arnab
Abstract excerpt
Alternative splicing (AS) coupled to nonsense-mediated decay (AS-NMD) is a conserved mechanism for post-transcriptional gene regulation. Here we show that, during dietary restriction (DR), AS is enhanced in Caenorhabditis elegans and mice. A splicing mediator hrpu-1 regulates a significant part of these AS events in C. elegans; knocking it down suppresses DR-mediated longevity. Concurrently, due to increased AS,...
Topics
- 3' Untranslated Regions
- Alternative Splicing
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Caloric Restriction
- Diet
- Exons
- Gene Expression Profiling
- Introns
- Longevity
- Mice
- Mutation
- Nonsense Mediated mRNA Decay