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Article

Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity.

Nature communications - 21 Aug 2017

Tabrez Syed Shamsh, Sharma Ravi Datta, Jain Vaibhav, Siddiqui Atif Ahmed, Mukhopadhyay Arnab

Abstract excerpt

Alternative splicing (AS) coupled to nonsense-mediated decay (AS-NMD) is a conserved mechanism for post-transcriptional gene regulation. Here we show that, during dietary restriction (DR), AS is enhanced in Caenorhabditis elegans and mice. A splicing mediator hrpu-1 regulates a significant part of these AS events in C. elegans; knocking it down suppresses DR-mediated longevity. Concurrently, due to increased AS,...

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PMID: 28824175
DOI: 10.1038/s41467-017-00370-5
PMCID: PMC5563511

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UPF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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