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Article

Pathophysiological Effects of Overactive STIM1 on Murine Muscle Function and Structure.

Cells - 8 Jul 2021

Silva-Rojas Roberto, Charles Anne-Laure, Djeddi Sarah, Geny Bernard, Laporte Jocelyn, Böhm Johann

Abstract excerpt

Store-operated Ca2+ entry (SOCE) is a ubiquitous mechanism regulating extracellular Ca2+ entry to control a multitude of Ca2+-dependent signaling pathways and cellular processes. SOCE relies on the concerted activity of the reticular Ca2+ sensor STIM1 and the plasma membrane Ca2+ channel ORAI1, and dysfunctions of these key factors result in human pathologies. STIM1 and ORAI1 gain-of-function (GoF) mutations...

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Source

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Identifiers

PMID: 34359900
DOI: 10.3390/cells10071730
PMCID: PMC8304505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pathophysiological Effects of Overactive STIM1 on Murine Muscle Function and Structure.PMID 34359900Read ↗

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