Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart.

The EMBO journal - 25 Feb 2004

Ding Jian-Hua, Xu Xiangdong, Yang Dongmei, Chu Pao-Hsien, Dalton Nancy D, Ye Zhen, Yeakley Joanne M, Cheng Heping, Xiao Rui-Ping, Ross John, Chen Ju, Fu Xiang-Dong

Abstract excerpt

Many genetic diseases are caused by mutations in cis-acting splicing signals, but few are triggered by defective trans-acting splicing factors. Here we report that tissue-specific ablation of the splicing factor SC35 in the heart causes dilated cardiomyopathy (DCM). Although SC35 was deleted early in cardiogenesis by using the MLC-2v-Cre transgenic mouse, heart development appeared largely unaffected, with the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy, Dilated
Share to Cell Death

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myocardial Contraction

Share to Myocytes, Cardiac

Share to Ribonucleoproteins

Share to Ryanodine Receptor Calcium Release Channel

Share to Serine-Arginine Splicing Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 14963485
DOI: 10.1038/sj.emboj.7600054
PMCID: PMC380988

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart.PMID 14963485Read ↗

An inherited life-threatening arrhythmia model established by screening randomly mutagenized mice.Semantic proximity Read ↗

Cardiac hypertrophy and arrhythmia in mice induced by a mutation in ryanodine receptor 2Semantic proximity Read ↗

<i>Dsp<sup>S311A</sup></i>knock-in mice replicate the clinical-pathological features of dominant and recessive forms of Desmoplakin-related cardiomyopathiesSemantic proximity Read ↗

Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse modelSemantic proximity Read ↗

Rbm20-deficient cardiogenesis reveals early disruption of RNA processing and sarcomere remodeling establishing a developmental etiology for dilated cardiomyopathySemantic proximity Read ↗

Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy.Semantic proximity Read ↗

Desmoplakin Cardiomyopathy: Gene Dose-Dependent Myocardial Remodeling, Arrhythmias, and Premature Death.Semantic proximity Read ↗

A novel murine model for arrhythmogenic cardiomyopathy points to a pathogenic role of Wnt signalling and miRNA dysregulationSemantic proximity Read ↗

Conditionally targeted deletion of PSEN1 leads to diastolic heart dysfunction.Semantic proximity Read ↗

REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defectsSemantic proximity Read ↗

Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes.Semantic proximity Read ↗

A Precision Medicine Approach to the Rescue of Function on Malignant Calmodulinopathic Long-QT SyndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.