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Article

Unraveling the nexus of nesprin in dilated cardiomyopathy: From molecular insights to therapeutic prospects.

Life sciences - 1 Dec 2024

Qin Qin, Zhou Zi-Yi, Liu Yangyuanzhi, Zhou Fei, Cao Chunyu, Teng Lin

Abstract excerpt

Dilated cardiomyopathy is a complex and debilitating heart disorder characterized by the enlargement and weakening of the cardiac chambers, leading to impaired contractility and heart failure. Nesprins, a family of nuclear envelope spectrin repeat proteins that include isoforms Nesprin-1/-2, are integral components of the LInker of Nucleoskeleton and Cytoskeleton complex. They facilitate the connection between...

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Identifiers

PMID: 39396640
DOI: 10.1016/j.lfs.2024.123126

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Unraveling the nexus of nesprin in dilated cardiomyopathy: From molecular insights to therapeutic prospects.PMID 39396640Read ↗

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