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Article

"Ryanopathies" and RyR2 dysfunctions: can we further decipher them using in vitro human disease models?

Cell death & disease - 1 Nov 2021

Sleiman Yvonne, Lacampagne Alain, Meli Albano C

Abstract excerpt

The regulation of intracellular calcium (Ca2+) homeostasis is fundamental to maintain normal functions in many cell types. The ryanodine receptor (RyR), the largest intracellular calcium release channel located on the sarco/endoplasmic reticulum (SR/ER), plays a key role in the intracellular Ca2+ handling. Abnormal type 2 ryanodine receptor (RyR2) function, associated to mutations (ryanopathies) or pathological...

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Identifiers

PMID: 34725342
DOI: 10.1038/s41419-021-04337-9
PMCID: PMC8560800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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