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Article

Lem2 is essential for cardiac development by maintaining nuclear integrity.

Cardiovascular research - 5 Sept 2023

Ross Jacob A, Arcos-Villacis Nathaly, Battey Edmund, Boogerd Cornelis, Orellana Constanza Avalos, Marhuenda Emilie, Swiatlowska Pamela, Hodzic Didier, Prin Fabrice, Mohun Tim, Catibog Norman, Tapia Olga, Gerace Larry, Iskratsch Thomas, Shah Ajay M, Stroud Matthew J

Abstract excerpt

AIMS: Nuclear envelope integrity is essential for the compartmentalization of the nucleus and cytoplasm. Importantly, mutations in genes encoding nuclear envelope (NE) and associated proteins are the second highest cause of familial dilated cardiomyopathy. One such NE protein that causes cardiomyopathy in humans and affects mouse heart development is Lem2. However, its role in the heart remains poorly understood....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37067297
DOI: 10.1093/cvr/cvad061
PMCID: PMC10478753

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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