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Article

Conditionally targeted deletion of PSEN1 leads to diastolic heart dysfunction.

Journal of cellular physiology - 1 Feb 2018

Song Xiao-Wei, Yuan Qing-Ning, Tang Ying, Cao Mi, Shen Ya-Feng, Zeng Zhen-Yu, Lei Chang-Hai, Li SongHua, Zhao Xian-Xian, Yang Yong-Ji

Abstract excerpt

Recently, PSEN1 has been reported to have mutations in dilated cardiomyopathy pedigrees. However, the function and mechanism of PSEN1 in cardiomyopathy remains unresolved. Here, we established four types of genetically modified mice to determine the function of PSEN1 in cardiac development and pathology. PSEN1 null mutation resulted in perinatal death, retardation of heart growth, ventricular dilatation, septum...

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Topics

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Share to Diastole
Share to Heart Defects, Congenital

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertrophy, Left Ventricular

Share to Myocardial Ischemia

Share to Myocytes, Cardiac

Share to Presenilin-1

Share to Ventricular Dysfunction, Left

Share to Ventricular Function, Left

Source

Identifiers

PMID: 28617969
DOI: 10.1002/jcp.26057

Genes

PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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