Article
REEP6 mediates trafficking of a subset of Clathrin-coated vesicles and is critical for rod photoreceptor function and survival.
Human molecular genetics - 15 Jun 2017
Veleri Shobi, Nellissery Jacob, Mishra Bibhudatta, Manjunath Souparnika H, Brooks Matthew J, Dong Lijin, Nagashima Kunio, Qian Haohua, Gao Chun, Sergeev Yuri V, Huang Xiu-Feng, Qu Jia, Lu Fan, Cideciyan Artur V, Li Tiansen, Jin Zi-Bing, Fariss Robert N, Ratnapriya Rinki, Jacobson Samuel G, Swaroop Anand
Abstract excerpt
In retinal photoreceptors, vectorial transport of cargo is critical for transduction of visual signals, and defects in intracellular trafficking can lead to photoreceptor degeneration and vision impairment. Molecular signatures associated with routing of transport vesicles in photoreceptors are poorly understood. We previously reported the identification of a novel rod photoreceptor specific isoform of Receptor...
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