Article
Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart.
Science translational medicine - 17 Jun 2015
Kaushik Gaurav, Spenlehauer Alice, Sessions Ayla O, Trujillo Adriana S, Fuhrmann Alexander, Fu Zongming, Venkatraman Vidya, Pohl Danielle, Tuler Jeremy, Wang Mingyi, Lakatta Edward G, Ocorr Karen, Bodmer Rolf, Bernstein Sanford I, Van Eyk Jennifer E, Cammarato Anthony, Engler Adam J
Abstract excerpt
The human heart is capable of functioning for decades despite minimal cell turnover or regeneration, suggesting that molecular alterations help sustain heart function with age. However, identification of compensatory remodeling events in the aging heart remains elusive. We present the cardiac proteomes of young and old rhesus monkeys and rats, from which we show that certain age-associated remodeling events...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.