Article
Single-molecule approaches to stochastic gene expression.
Annual review of biophysics - 1 Jan 2009
Raj Arjun, van Oudenaarden Alexander
Abstract excerpt
Both the transcription of mRNAs from genes and their subsequent translation into proteins are inherently stochastic biochemical events, and this randomness can lead to substantial cell-to-cell variability in mRNA and protein numbers in otherwise identical cells. Recently, a number of studies have greatly enhanced our understanding of stochastic processes in gene expression by utilizing new methods capable of...
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