Article
MeCP2 is involved in random mono-allelic expression for a subset of human autosomal genes.
Biochimica et biophysica acta. Molecular basis of disease - 1 Jun 2020
Brousseau Marine, Nectoux Juliette, Saintpierre Benjamin, Lebrun Nicolas, Cagnard Nicolas, Izac Brigitte, Olivier Emmanuelle, Letourneur Franck, Bienvenu Thierry
Abstract excerpt
Widespread random monoallelic gene expression (RMAE) effects influence about 10% of human genes. However, the mechanisms by which RME of autosomal genes is established and those by which it is maintained both remain open questions. Because the choice of allelic expression is randomly performed cell-by-cell, the RMAE mechanism is not observable in non-clonal cell populations or in whole tissues. Several target...
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