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Article

Developmental dynamics and disease potential of random monoallelic gene expression.

Developmental cell - 24 Feb 2014

Gendrel Anne-Valerie, Attia Mikael, Chen Chong-Jian, Diabangouaya Patricia, Servant Nicolas, Barillot Emmanuel, Heard Edith

Abstract excerpt

X chromosome inactivation (XCI) and allelic exclusion of olfactory receptors or immunoglobulin loci represent classic examples of random monoallelic expression (RME). RME of some single copy genes has also been reported, but the in vivo relevance of this remains unclear. Here we identify several hundred RME genes in clonal neural progenitor cell lines derived from embryonic stem cells. RME occurs during...

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PMID: 24576422
DOI: 10.1016/j.devcel.2014.01.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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